Products

VP-ITC Isothermal Titration Calorimeter

The VP-ITC system is an ultrasensitive isothermal titration calorimeter designed for ease-of-use.  All functions are operated through software to minimize operator involvement and facilitate fast and accurate analyses without the need for expertise in thermodynamics.

The capabilities of ITC as a technique, combined with the unique performance features of the VP-ITC have made this system the best selling ultrasensitive isothermal titration calorimeter in the world.

Applications include:

  • Characterization of molecular interactions of small molecules, proteins, antibodies, nucleic acids, lipids and other biomolecules.
  • Lead optimization.
  • Enzyme kinetics.
  • Assessment of the effect of molecular structure changes on binding mechanisms.
  • Assessment of biological activity.

Why VP-ITC?

  • More than just affinities:  Simultaneous determination of all binding parameters in a single experiment - information unobtainable from more limited binding assays.
  • Directly measure sub-millimolar to nanomolar binding constants (102 to 109 M-1).  Measure nanomolar to picomolar binding constants (109 to 1012 M-1) using the competitive binding technique.
  • Application versatility:  Investigate any biomolecular interaction with high sensitivity.
  • True in-solution technique: No labeling or immobilization required. No buffer restrictions. Easily handles turbid solutions.
  • Easy to use: Unattended operation after sample loading.
  • Complete system: No additional accessories to purchase.  No reagents are required.

VP-ITC features:

  • Active cell volume ~ 1.4 ml.
  • Non-reactive Hastelloy® cells for excellent chemical resistance.
  • Fixed-in-place cells for reproducible ultrasensitive performance with low maintenance.
  • Precision liquid delivery system for accurate and reproducible injections.
  • User-selectable mixing speeds to match sample conditions.
  • Three user selectable response times (U.S. Patent number 5,967,659) for application versatility.  
  • Operating temperature range of 2ºC to 80ºC.
  • Peltier controlled for rapid temperature equilibration.
  • Includes ThermoVac® sample preparation and cleaning device.
  • Now includes Single Injection Method software.

Need more information? Contact us.

VP-ITC Isothermal Titration Calorimeter